Peptides derived from the heavy chain of the HLA Class-I molecules have been shown to modulate immune responses both in vivo and in vitro. Using a computer-aided rational drug design approach, novel immunomodulatory peptides were designed based on peptide 2702.75–85, derived from HLA-B2702. Several peptides were identified which had increased immunomodulatory activity, including peptides RDP1258 and its d-isomer the peptide Allotrap 1258. The present study using Skh/hr hairless mouse skin model evaluated the in vivo effects of Allotrap 1258 on acute UVB-induced skin inflammation. Here we demonstrate that intraperitoneal administration of Allotrap 1258 1 h prior to UV exposure resulted in significantly diminished levels of UV-induced tumor necrosis factor (TNF)-α protein production in the epidermis but had no effect on other parameters of the acute UV-induced inflammatory response. By virtue of its ability to suppress TNF-α protein production, Allotrap 1258 could prove to be an effective modulator of inflammatory responses.
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1 February 2001
Inhibition of Cutaneous UV Light–induced Tumor Necrosis Factor-α Protein Production by Allotrap 1258, a Novel Immunomodulatory Peptide
Tatiana M. Oberyszyn,
Fredika M. Robertson,
Kathleen L. Tober,
Mary S. Ross,
Michelle L. Parrett,
Traci A. Wilgus,
Suhasini Iyer,
Jacky Woo,
Roland Buelow
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Photochemistry and Photobiology
Vol. 73 • No. 2
February 2001
Vol. 73 • No. 2
February 2001